About Company
Caribou Biosciences is a leading clinical-stage CRISPR genome-editing company, revolutionizing medicine with next-generation CAR-T and natural killer (NK) cell therapies. Harnessing the power of CRISPR hybrid RNA-DNA (chRDNA) guides, our groundbreaking technologies enable the precise, efficient, and durable editing of genes to create transformative solutions for patients with significant unmet medical needs. Founded by pioneers in CRISPR technology, Caribou is committed to advancing innovative treatments across oncology and other serious diseases. We foster a dynamic, collaborative, and scientifically rigorous environment where discovery and development thrive.
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Job Description
Caribou Biosciences is seeking a highly motivated and skilled Bioengineer to join our Process Development team in Berkeley, CA. In this critical role, you will be instrumental in developing, optimizing, and scaling manufacturing processes for our cutting-edge gene-edited cell therapies. This position offers an exciting opportunity to contribute to the advancement of next-generation CRISPR-based therapeutics, working at the forefront of genetic engineering and cellular manufacturing. You will apply principles of biochemical engineering, cell biology, and analytical science to design and execute experiments, analyze complex data, and translate laboratory-scale processes into robust, scalable, and reproducible manufacturing platforms. The ideal candidate will possess a strong scientific foundation, excellent problem-solving abilities, and a passion for innovation within the biotechnology sector. If you are a collaborative scientist with a drive to make a tangible impact on patient lives through pioneering technology, we encourage you to apply.
Key Responsibilities
- Design, execute, and analyze experiments to develop and optimize upstream and downstream processes for gene-edited cell therapies, including cell culture, transfection, purification, and formulation.
- Utilize advanced bioreactor systems and process analytical technologies (PAT) to monitor and control critical process parameters (CPPs) and critical quality attributes (CQAs).
- Perform extensive data analysis, interpretation, and visualization to drive process understanding and improvement, utilizing statistical software (e.g., JMP, R).
- Develop and qualify analytical methods for in-process testing, product characterization, and release testing.
- Author detailed technical reports, study protocols, and standard operating procedures (SOPs) in accordance with regulatory guidelines.
- Collaborate cross-functionally with Research, Analytical Development, Manufacturing, and Quality teams to ensure seamless technology transfer and product advancement.
- Stay current with scientific literature and industry trends in cell and gene therapy manufacturing, incorporating new technologies and strategies into process development efforts.
- Present findings and recommendations to internal stakeholders and contribute to scientific publications and patent applications.
Required Skills
- Ph.D. in Bioengineering, Chemical Engineering, Biotechnology, or a related field with 0+ years of industry experience OR M.S. with 3+ years of relevant industry experience OR B.S. with 5+ years of relevant industry experience.
- Proven experience in mammalian cell culture and bioreactor operations (e.g., stirred tank, rocking motion).
- Strong understanding of biological processes, including cell metabolism, protein expression, and gene editing technologies (e.g., CRISPR).
- Proficiency in experimental design (DoE) and statistical analysis for process optimization.
- Familiarity with analytical techniques such as flow cytometry, ELISA, qPCR, and HPLC.
- Excellent written and verbal communication skills, with the ability to present complex data clearly and concisely.
- Demonstrated ability to work independently and as part of a collaborative, interdisciplinary team.
Preferred Qualifications
- Experience with aseptic processing and Good Manufacturing Practice (GMP) principles.
- Proficiency in automation and high-throughput screening technologies.
- Prior experience in cell and gene therapy process development, particularly with allogeneic cell products.
- Knowledge of viral vector production and characterization.
- Familiarity with process modeling and simulation tools.
Perks & Benefits
- Competitive salary and stock options.
- Comprehensive medical, dental, and vision insurance.
- 401(k) retirement plan with company match.
- Generous paid time off and holidays.
- Flexible spending accounts and commuter benefits.
- On-site fitness center and wellness programs.
- Professional development and continuing education opportunities.
- Fully stocked kitchen with snacks and beverages.
- Collaborative and inclusive company culture.
- Cutting-edge lab facilities and equipment.
How to Apply
To be considered for this exciting opportunity, please click on the application link below. You will be redirected to our careers page where you can submit your resume and cover letter directly. We look forward to reviewing your qualifications!
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